How does chronic pain shapes the anatomy of the brain? What biological pathways might explain the vulnerability of certain brain regions to these changes? Here, we examined alterations in morphometric similarity and applied an integrative imaging transcriptomics approach to identify transcriptional and cellular correlates of these MS changes, in three independent small cohorts of patients with distinct chronic pain syndromes (knee osteoarthritis, low back pain and fibromyalgia) and age and sex-matched pain-free controls. 

REF: Martins et a, Transcriptional and cellular signatures of cortical morphometric remodelling in chronic pain, PAIN (2021)

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